J Forensic Sci. 2011 Aug 9. doi: 10.1111/j.1556-4029.2011.01867.x. [Epub ahead of print]

Comparisons of Familial DNA Database Searching Strategies.

Ge J, Chakraborty R, Eisenberg A, Budowle B.

Source

Department of Forensic and Investigative Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107. Institute of Investigative Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107.

The current familial searching strategies are generally based on either Identity-By-State (IBS) (i.e., number of shared alleles) or likelihood ratio (i.e., kinship index [KI]) assessments. In this study, the expected IBS match probabilities given relationships and the logic of the likelihood ratio method were addressed. Further, the false-positive and false-negative rates of the strategies were compared analytically or by simulations using Caucasian population data of the 13 CODIS Short Tandem Repeat (STR).

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